Deleuze studied philosophy at the Sorbonne under a generation of teachers that included Ferdinand Alquié, Jean Hyppolite, Georges Canguilhem, and Maurice de Gandillac. His early work operated in the mode of creative commentary on philosophical predecessors — books on Hume (1953), Nietzsche (1962), Kant (1963), Bergson (1966), Spinoza (1968), and Leibniz (1988). These were not straightforward interpretations but philosophical interventions that used the predecessor as a resource for developing Deleuze's own project.
The encounter with Félix Guattari in 1969 transformed Deleuze's work. Guattari was a practicing psychoanalyst at the La Borde clinic, deeply involved in the political movements of May 1968, and committed to developing forms of thought that could address the new configurations of power emerging in late twentieth-century societies. Their collaboration produced Anti-Oedipus: Capitalism and Schizophrenia (1972) and A Thousand Plateaus: Capitalism and Schizophrenia Vol. 2 (1980) — two volumes that remain among the most ambitious, controversial, and productive philosophical works of the late twentieth century.
Deleuze taught at the experimental University of Paris VIII–Vincennes-Saint-Denis from 1970 until his retirement in 1987. His lectures, many of which have been transcribed and published, were legendary for their intensity and their refusal of conventional academic forms. He lived through the intellectual ferment of post-1968 Paris alongside Foucault, Derrida, Lyotard, and Lacan, but maintained a distinctive philosophical identity that resisted easy classification as structuralist, post-structuralist, or any other movement label.
In his final decade, Deleuze suffered increasingly severe respiratory illness — a legacy of tuberculosis contracted in his youth — that confined him to his Paris apartment. During this period he wrote the Postscript on the Societies of Control (1990), his essay on Beckett The Exhausted (1992), and his final solo book What Is Philosophy? (1991, with Guattari). On November 4, 1995, unable to bear the deterioration of his respiratory function, he took his own life by falling from the window of his apartment on the Rue de Bizerte. The death was, in its terrible way, consistent with the philosophical commitment to lines of flight that his work had theorized.
Deleuze's philosophical formation was shaped by the specific institutional and intellectual conditions of postwar French philosophy: the encounter with phenomenology and existentialism in the 1950s, the structuralist moment of the 1960s, the political upheaval of 1968, and the post-structuralist reconfigurations of the 1970s and 1980s. He belonged to a generation that took philosophy to be an urgent and public activity, and that believed new conceptual tools were necessary to address transformations in power, subjectivity, and technology that inherited frameworks could not adequately analyze.
Philosophy as creation of concepts. Deleuze insisted that philosophy's task is not to interpret reality through given categories but to create new concepts adequate to the problems of a specific moment.
Difference as fundamental. Against philosophical traditions that treated difference as a derivative of identity, Deleuze argued that difference is primary and identity is an effect of differential processes.
The plane of immanence. Deleuze rejected transcendent foundations for thought in favor of what he called the plane of immanence — a field in which concepts are developed through their internal connections rather than grounded in external principles.
Power as modulation, not repression. The Postscript's analysis of control societies advanced a conception of power that operates through continuous adjustment rather than through prohibition and enclosure.
Resistance through creation, not opposition. Genuine transformation happens through lines of flight that produce novelty the system cannot absorb, not through direct confrontation with existing configurations.