The finding emerges not from a single experiment but from the cumulative weight of Selye's research program demonstrating that the GAS operates identically across stressors the organism experiences as beneficial (exercise, challenge, growth) and stressors it experiences as harmful (illness, trauma, deprivation).
The technology industry's celebration of intense enjoyable work — the 'never worked this hard or had this much fun' narrative — represents, in Selye's framework, a systematic misuse of the pleasure signal as a sustainability indicator. The pleasure is real, but it tracks the dopaminergic reward of productive interaction, not the depletion of the reserves that sustain the interaction.
The clinical implication is that employee engagement surveys, flow-state measurements, and self-reported satisfaction are inadequate instruments for organizational health assessment in AI-augmented work. They measure the hedonic signal and assume it tracks the physiological cost. The two can diverge for extended periods — the late resistance phase is precisely the period when they most dangerously diverge.
Objective monitoring — heart rate variability, sleep architecture, inflammatory markers, diurnal cortisol rhythm — provides the data that subjective experience systematically conceals. The instruments track the physiological cost rather than the hedonic signal, and they detect the divergence between feeling and function that the resistance phase produces.
The finding is distributed across Selye's corpus rather than localized to a single paper. It emerges most explicitly in his insistence throughout Stress Without Distress that eustress refers to outcome, not experience — a distinction he found necessary because the experience-based reading of his framework had become widespread.
Separate neural substrates. Reward systems and stress-response systems operate on different neural substrates — they can diverge for extended periods.
Metabolic cost is indifferent to valence. The hormonal response tracks the metabolic cost of the activity, not the emotional relationship to the activity.
Pleasure masks cost. The hedonic signal systematically obscures the physiological cost during the resistance phase.
Engagement surveys as inadequate. Self-report instruments that measure satisfaction cannot detect the divergence between feeling and function that predicts collapse.
Objective monitoring as corrective. Heart rate variability, sleep architecture, and inflammatory markers track what subjective experience cannot — the biological cost of sustained demand.