The alarm reaction is metabolically expensive in ways that matter. The surge of cortisol and adrenaline draws on glycogen reserves, redirects blood flow from digestive and reproductive systems toward muscles and brain, and suppresses immune function. These costs are manageable when the reaction is brief. They become damaging when the reaction is sustained or repeatedly triggered before full recovery.
Selye identified the alarm reaction as taxonomically prior to the fight-or-flight response Walter Cannon had earlier described. Fight and flight are both resolutions of the alarm — two branches of the sympathetic response that the organism's assessment of controllability determines. The alarm itself is the state of acute readiness that precedes either resolution.
The piling-up pattern Selye documented — repeated alarm reactions in rapid succession before adaptation to the previous alarm is complete — is the most efficient route to exhaustion his experiments revealed. The technology community in 2025 and 2026 experienced precisely this pattern as each model release triggered a fresh alarm before the previous adaptation was consolidated.
Toffler's future shock describes the psychological correlate of sustained alarm at civilizational scale. What Toffler named as disorientation, Selye's framework identifies as the hormonal state of an organism whose alarm system has been continuously triggered by an environment changing faster than adaptation can consolidate.
Selye first described the alarm reaction in his 1936 Nature letter, documenting the triphasic pattern across diverse stressors. He formalized its physiology through three decades of subsequent research at the Université de Montréal, establishing the HPA axis cascade as the neuroendocrine mechanism.
Acute mobilization. The alarm activates every system simultaneously — cardiovascular, metabolic, cognitive, immune-suppressive — in a single coordinated response.
Binary resolution. The alarm resolves into either engagement (leading to resistance phase adaptation) or withdrawal (leaving the stressor unresolved and the alarm chronically low-grade).
Novelty-dependence. The alarm re-fires each time the organism encounters fresh novelty — habituation requires stable conditions that rapidly changing environments do not provide.
Approach-avoidance oscillation. When threat-detection and reward-seeking systems are simultaneously activated by the same stimulus, the organism displays the oscillating behavior Segal describes as vertigo.
Controllable versus uncontrollable framing. The same alarm intensity produces qualitatively different physiological outcomes depending on whether the organism perceives the stressor as controllable — a finding with direct implications for the engage-or-retreat decision.