The practical wisdom — analogous to ancient metis — that enables practitioners to manage their relationship with technical objects across the duration of use.
Pharmacological knowledge is the form of savoir-faire specifically concerned with the dual nature of technical objects. It is not a body of doctrine that can be memorized and applied. It is practical wisdom developed through repeated engagement with the pharmakon under conditions that permit the practitioner to develop a feel for its dynamics — when remedy becomes poison, when flow becomes compulsion, when output outpaces understanding. Stiegler linked it to the ancient Greek concept of metis, the cunning intelligence of the helmsman, the physician, the craftsman: contextual judgment developed through engagement rather than derived from principle.
Pharmacological Knowledge
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The concept answers the question: what discipline does therapeutic adoption require of the practitioner? The answer cannot be a rule-set, because the pharmacological situation is too context-dependent for rules to govern adequately. It must be a cultivated capacity, built through the specific practice of attending to one's own pharmacological relationship with the tool.
Segal demonstrates pharmacological knowledge in action at several points. The Deleuze verification — recognizing, against